The Metamorphosis takes place in the small apartment where Gregor lives with his family. The city and time period are unspecified, though references to trains and streetcars suggest the late-nineteenth century or early twentieth century.
Gregor’s room lies sandwiched right between the rooms of his sister and his parents. This rpopably symbolizes the oppression the main character feels from society and his family in particular. Gregor might feel a lack of freedom as he lives right in the middle of his family and does not have his own place to stay.
The setting creates a theme of isolation as when he becomes an insect, Gregor is physically isolated from his family and from human society in general. A small bedroom in the middle of the apartment is a place where he will spend most of the rest of his life after his transformation.