Genetically Predisposed Individuals: [Essay Example], 461 words GradesFixer

Haven't found the right essay?

Get an expert to write your essay!


Professional writers and researchers


Sources and citation are provided


3 hour delivery


Haven't found the right essay?

Get an expert to write your essay!

This essay has been submitted by a student. This is not an example of the work written by professional essay writers.

Genetically Predisposed Individuals

Print Download now

Pssst… we can write an original essay just for you.

Any subject. Any type of essay.

We’ll even meet a 3-hour deadline.

Get your price

121 writers online

Download PDF

I am a basic biochemist and interested in events that takes place in cancer biology at the molecular level. I found interesting that RNA biology and its under lying events plays a crucial role in the afore mentioned. My primary goal is to understand the basic and fundamental mechanisms of protein synthesis and determine how these mechanisms contribute to both normal and disease states, in particular, Celiac Disease and cancer. The major mechanism to regulate protein synthesis is at the step of initiation. Initiating translation of a messenger RNA requires recruiting the ribosome to the mRNA and positioning it at the initiator codon (AUG). The major mechanism for these processes is called the cap/scanning model whereby the cap-binding protein binds the very 5′ end of the mRNA, the 7 methyl guanosine triphosphateand recruits the translational machinery including the 40S ribosome. The ribosome, in turn, migrates or scans along the 5′ leader until it encounters an AUG in a proper context. An alternative and less well understood mechanism is the recruitment of the ribosome by the 5′ leader.

These regions downstream of the cap structure are called internal ribosomal entry sites (IRESes). IRESes have been best studied under various clinical conditions and in a subset of viruses including poliovirus and Hepatitis C. To date, only a small percentage of eukaryotic mRNAs have been shown to contain an IRES and the mechanism and function of these eukaryotic IRESes is not well understood. It is proposed that conditions that inhibit or down-regulate cap-dependent translation maintain or up-regulate IRES-dependent translation. These same conditions contribute to cancer. My ultimate research goal is to identify IRESes in mRNAs that code for proteins that are essential for the etiology that contribute to carcinogenesis (Aurora A Kinase). In addition, i am interested in examining the regulation (or mis-regulation) of the above IRESes in part by identifying intracellular signaling pathways that potentially lead to the post-translational modification of specific RNA-binding proteins in culture as well as the creation of transgenic animals which can be well used for my research as well as for the future generation. Celiac disease (CD) is a chronic immune-mediated disorder triggered by the ingestion of gluten in genetically predisposed individuals. Before activating the immune system, gluten peptides are transferred by the epithelial barrier to the mucosal lamina propria, where they are deamidated by intestinal tissue transglutaminase

2. When it comes to celiac disease in India the research is mainly focused on clinical rather than the pharmacological. Many journals have been published but most of them have reported the clinical case studies. These is no retrospective study published till date and the number of subjects affected or the underlying facts behind has not yet to be brought to the lime light for the benefits of the public.

Remember: This is just a sample from a fellow student.

Your time is important. Let us write you an essay from scratch

100% plagiarism free

Sources and citations are provided

Cite this Essay

To export a reference to this article please select a referencing style below:

GradesFixer. (2019, November, 26) Genetically Predisposed Individuals. Retrived May 26, 2020, from
"Genetically Predisposed Individuals." GradesFixer, 26 Nov. 2019, Accessed 26 May 2020.
GradesFixer. 2019. Genetically Predisposed Individuals., viewed 26 May 2020, <>
GradesFixer. Genetically Predisposed Individuals. [Internet]. November 2019. [Accessed May 26, 2020]. Available from:

Sorry, copying is not allowed on our website. If you’d like this or any other sample, we’ll happily email it to you.

By clicking “Send”, you agree to our Terms of service and Privacy statement. We will occasionally send you account related emails.


Attention! this essay is not unique. You can get 100% plagiarism FREE essay in 30sec

Recieve 100% plagiarism-Free paper just for 4.99$ on email
get unique paper
*Public papers are open and may contain not unique content
download public sample

Sorry, we cannot unicalize this essay. You can order Unique paper and our professionals Rewrite it for you



Your essay sample has been sent.

Want us to write one just for you? We can custom edit this essay into an original, 100% plagiarism free essay.

thanks-icon Order now

Hi there!

Are you interested in getting a customized paper?

Check it out!
Having trouble finding the perfect essay? We’ve got you covered. Hire a writer uses cookies. By continuing we’ll assume you board with our cookie policy.