New treatment Approaches and Therapeutic Alternatives

In the recent time, it has been said that MRSA infections in the western countries like America has increased and the mortality rate is increased than the AIDS. Life-threatening diseases are caused by toxins from CA-MRSA strain like Panton-Valentine Leukocidin (PVL) and Phenol-Soluble Modulins (PSM).

About three half of the infection affects the skin and soft tissues in the body. There are several drugs which were introduced into the action and were got resisted. There are some conditions to be fulfilled for getting an effective antibiotic like antibiotic target must exist inside the bacterial cell, an effective amount of antibiotic must be reached in the targeted site, the antibiotic should not get metabolized. Introduction of third-generation cephalosporins shows a wide coverage using a single therapeutic agent.

A number of studies have shown that monotherapy is better than combination therapy Daptomycin, a cyclic lipopeptide antibiotic was used to treat both CA-MRSA and HA-MRSA. It acts by disrupting the bacterial cell wall leading to its lysis. It was accepted due to its safe line but it got inactivated by pulmonary surfactants. Vancomycin was used to overcome the infection. It was selected due to its safety profile and insufficient active drug. Use of this was stopped due to the evolution of Vancomycin Intermediate Resistant Staphylococcus Aureus (VISA). Chemotherapy using linezolid was limited due to its expenses. There several antibiotics like glycylcycline antibiotic, cephalosporins (due to its affinity on PBPs) were used[25]. There are several types of research undergoing to develop new drugs with a novel action against MRSA.

Development of novel drugs should be able to overcome the resistance offered and its actions should involve shortening the therapy schedule, harmful effects should be reduced or eradicated, moreover, the resistance should be eradicated and the combination therapies must have excellent efficacy. Contemporary details of the research can be sited on several websites. Some of the recent studies in MRSA had come out and several industries are working to get a result. Some of the studies and inventions of different companies are mentioned below

The era of antibiotic dominance has been coming to extinct after the brunt of bacteria against antibacterials. Growing infections are impossible to treat and lead to severe health care risks. WHO mentioned that newly discovered agents are not effective against highly resistant bacteria. Most of the phytoconstituents are having an effective antibacterial effect but the technique of isolation and search should be systematically done to get a proper effective antibiotic with a safer margin of action. Since the present antibiotics are resisted in action, the novelty of new antimicrobial must overcome it.