close
This essay has been submitted by a student. This is not an example of the work written by professional essay writers.

Study of Serum Vitamin B12 and Vitamin D Levels in Patients of Cirrhosis

downloadDownload printPrint

Pssst… we can write an original essay just for you.

Any subject. Any type of essay.

We’ll even meet a 3-hour deadline.

Get your price

121 writers online

blank-ico
Download PDF

“Cirrhosis is defined as the histological development of regenerative nodules surrounded by fibrous bands in response to chronic liver injury, leading to portal hypertension and End Stage Liver Disease (ESLD) progressing to Cirrhosis and finally leading to decompensated liver disease.”

Cirrhosis is one of the leading causes of death in Asia as it ranks tenth most common cause of death in US, whereas worldwide, it is the 12th most common cause. Medical treatments that may slow down the progression of compensated cirrhosis to decompensated cirrhosis are under research phase. Liver Transplantation is however the only option in a selected subgroup of patients with ESLD and HCC.

Vitamin D is also known to have multiple extraskeletal functions. The liver is the main organ involved in the synthesis and metabolism of vitamin D after kidneys. 25-hydroxylation occurs inliver thereby converting it into active form. There are various experimental studies have demonstrated an increase in vitamin D deficiency prevalance and its insufficiency in patients with chronic liver disease and cirrhosis. It is often seen that sometimes even in the absence of cirrhosis, vitamin D deficiency may be detected in the majority of subjects. However those subjects who had cirrhosis, vitamin D deficiency(<25 nmol/L)prevalance increased with the increase in severity of liver dysfunction. There is an emerging interest to explore the relationship between vitamin D deficiency and prevalence and severity of non-alcoholic liver disease.

There are various studies that state that vitamin D deficiency is related to the pathophysiology of cirrhosis.There are studies which have proven (to some extent) that levels of vitamin d are inversly correlated with liver dysfunction as evidenced by Child Pugh score and MELD score Also, vitamin D deficiency has been implicated for increase in the risk for overall mortality and infections in patients with cirrhosis. Recently, a study revealed an increase in MELD score seen in transplant cases to be associated with deficiency of Vitamin D.

The liver storage organ for fat soluble vitamins, vitamin B12 is one of them. Liver stores an estimated 1 mg of it. In Patients with chronic liver disease or cirrhosis serum vitamin B12 is often found to be elevated of serum vitamin B12 and However its normal values were also found in some patients, particularly in long-standing portal cirrhosis.

Some studies have indicated that elevated serum levels of vitamin B12 might be a sign of a serious and life-threatening disease. It has been observed that highly elevated vitamin B12 levels in patients with advanced stages of viral liver cirrhosis. There are only one report that demonstrated the association of vitamin B12 level with disease severity and mortality in hepatitis B virus infection with short term. No reports have evaluated the dynamics of vitamin B12 in chronic viral hepatitis. Accordingly, the present study aimed to evaluate the relationship of serum vitamin B12 between the disease severity and long term prognosis of liver disease in patients with cirrhosis.

infoRemember: This is just a sample from a fellow student.

Your time is important. Let us write you an essay from scratch

100% plagiarism-free

Sources and citations are provided

Find Free Essays

We provide you with original essay samples, perfect formatting and styling

Cite this Essay

To export a reference to this article please select a referencing style below:

Study of Serum Vitamin B12 and Vitamin D Levels in Patients of Cirrhosis. (2018, December 17). GradesFixer. Retrieved June 12, 2021, from https://gradesfixer.com/free-essay-examples/study-of-serum-vitamin-b12-and-vitamin-d-levels-in-patients-of-cirrhosis/
“Study of Serum Vitamin B12 and Vitamin D Levels in Patients of Cirrhosis.” GradesFixer, 17 Dec. 2018, gradesfixer.com/free-essay-examples/study-of-serum-vitamin-b12-and-vitamin-d-levels-in-patients-of-cirrhosis/
Study of Serum Vitamin B12 and Vitamin D Levels in Patients of Cirrhosis. [online]. Available at: <https://gradesfixer.com/free-essay-examples/study-of-serum-vitamin-b12-and-vitamin-d-levels-in-patients-of-cirrhosis/> [Accessed 12 Jun. 2021].
Study of Serum Vitamin B12 and Vitamin D Levels in Patients of Cirrhosis [Internet]. GradesFixer. 2018 Dec 17 [cited 2021 Jun 12]. Available from: https://gradesfixer.com/free-essay-examples/study-of-serum-vitamin-b12-and-vitamin-d-levels-in-patients-of-cirrhosis/
copy to clipboard
close

Sorry, copying is not allowed on our website. If you’d like this or any other sample, we’ll happily email it to you.

    By clicking “Send”, you agree to our Terms of service and Privacy statement. We will occasionally send you account related emails.

    close

    Attention! This essay is not unique. You can get a 100% Plagiarism-FREE one in 30 sec

    Receive a 100% plagiarism-free essay on your email just for $4.99
    get unique paper
    *Public papers are open and may contain not unique content
    download public sample
    close

    Sorry, we could not paraphrase this essay. Our professional writers can rewrite it and get you a unique paper.

    close

    Thanks!

    Your essay sample has been sent.

    Want us to write one just for you? We can custom edit this essay into an original, 100% plagiarism free essay.

    thanks-icon Order now
    boy

    Hi there!

    Are you interested in getting a customized paper?

    Check it out!
    Having trouble finding the perfect essay? We’ve got you covered. Hire a writer
    exit-popup-close

    Haven't found the right essay?

    Get an expert to write you the one you need!

    exit-popup-print

    Professional writers and researchers

    exit-popup-quotes

    Sources and citation are provided

    exit-popup-clock

    3 hour delivery

    exit-popup-persone