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About this sample
About this sample
Words: 668 |
Page: 1|
4 min read
Published: Sep 25, 2018
Words: 668|Page: 1|4 min read
Published: Sep 25, 2018
Vesiculobullous disorders represent a heterogenous group of dermatoses with protean manifestations Vesicles and Bullae are fluid filled cavities formed within or beneath the epidermis. In this study, skin punch biopsy is used for diagnosis. Punch biopsy is a simple, inexpensive, safe OPD procedure, causing minimal discomfort to the patient and no scarring. These disorders have remarkable impact on the patient and their family, and have severe economic consequences.
Pathologic evaluation of blisters involves systematic analysis, which includes the blister separation plane, the mechanism of blister formation and the character of the inflammatory infiltrate, including its presence or absence. Recent advances in investigative dermatology have created new horizons. The most important techniques for the investigation of patients with Vesiculobullous disease are conventional histopathology and confirmative tests like direct and indirect immunofluorescence
Immunofluorescence has a very important role in the diagnosis, treatment and understanding of the pathophysiology of Vesiculobullous lesions of skin. It is also an important prognostic tool, as positive direct immunofluorescence (DIF) findings in patients in remission predict early relapse of disease Research techniques such as immunoblotting and immunoelectron microscopy may refine the diagnosis in the individual patient. However, these investigations are available only in advanced research laboratories. DIF is also done only in a few centres in developing countries like India. With the availability of transport media like Michel’s media, majority of dermatologists can have access to DIF.Therefore,this study is an attempt to evaluate Vesiculobullous lesions using both histopathology and direct IF (DIF) studies and to assess the diagnostic potential of the IF studies.
The most common being Pemphigus vulgaris followed by bullous pemphigoid, pemphigus foliaceous and dermatitis herpetiformis. In a present study expecting similar proportions considering absolute precision of 4% to achieve a desired confidence level of 95% the sample size worked out to 68 cases of Vesiculobullous lesions.
Through this study we aim to categorize Vesiculobullous lesions based on their response to IF. We aim to find a quicker and accurate diagnosis for Vesiculobullous skin lesions that are difficult to diagnose on the basis of clinical and histopathological features. So, in this study we corelate and evaluate the clinical findings of Vesiculobullous lesions with positive or negative results of histopathological and IF evaluation.
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