Nanoscience in The Future

Nanomaterials have received much attention because their structure and properties differ significantly from those of atoms, molecules, and bulk materials [1]. The synthesis of metal nanoparticles has been widely discussed in the literature due to their unique physical and chemical properties, which have many potential applications. [2–4] The use of inexpensive chemicals and non-toxic solvents – environmentally friendly and renewable/biodegradable – are central to materials synthesis and processing, considering the green nature of these strategies. In the past decade, green nanoparticle synthesis has evolved into an important branch of nanotechnology because of its potential application in the biomedical, magnets, energy science and aerospace industries. Large amounts of nanoparticles can be easily synthesized from plants and the majority of these are nontoxic. [5-8] They have been used in pharmaceutical drug-based industries to treat B-chronic lymphocytic leukemia, for detecting DNA, to inhibit bacteria and fungi, and to prevent burns and open wound infections. [9-12] Several techniques, such as chemical, electrochemical, radiation, photochemical, and biological, have been used for the biosynthesis of silver and gold nanoparticles.[13-15]

In recent years, Nanoscience has increased and expanded from a multidisciplinary research concept to a primary scientific frontier. Rapid technological advancements have led to the expansion of nanoscale device components, advanced sensors, and novel biomimetic materials.[16-18] Among the noble metals, silver nanoparticles have received considerable attention due to their attractive physicochemical properties, such as magnetic and optical polarizability, electrical conductivity, catalysis, antimicrobial behavior, DNA sequencing, surface-enhanced Raman scattering, and thermal properties.[18-20] Silver nanoparticles have been found to have strong antimicrobial activity, and are used in wound dressings, contraceptive devices, surgical instruments, bone prostheses, and as a coating for ocular lenses to prevent microbial activity.[21-23] However, the potentially negative impacts of nanomaterials are sometimes overlooked during the discovery phase of research. The implementation of green chemistry principles can enhance Nanoscience by maximizing safety and efficiency while minimizing the environmental and societal impacts of these materials. Using plant extracts for nanoparticle synthesis can be advantageous over other biological processes because it eliminates the elaborate process of maintaining cell cultures and can also be suitably scaled up for large-scale nanoparticle synthesis.[24]

In this present report, we have developed a simple one-step green chemistry approach for the

Synthesis of colloidal silver nanoparticles using Aloe vera extract, it acts as reducing agent as well as stabilizing/capping agent in the synthesis of nanoparticles (25), (ii) Aloe Vera is a medicinally important herbal plant useful for the treatment of several diseases such as anti-cancer (26-28), anti-bacterial (29), headache (30), and psoriasis (31). Additionally, a plausible mechanistic approach has been investigated for the anti-cancer activity of b-AgNPs. The results together will provide the basic foundation for the development of the versatile application of biosynthesized AgNPs towards biomedical technology in near future.